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Diclofenac is a common nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, such as in arthritis, menstrual cramps, migraines, and injuries. It works by blocking the production of prostaglandins, which are chemicals that cause pain, swelling, and fever in response to injury or illness. While diclofenac is available in various forms, such as tablets, capsules, injections, and suppositories, two of the most popular forms are oral tablets and topical gels. How do they compare?

Diclofenac tablets

Diclofenac tabletDiclofenac tablets are taken by mouth, usually two to three times a day with or after food or milk to reduce the risk of stomach upset. The usual dose for adults is 50 mg to 150 mg per day, depending on the condition and response. Diclofenac tablets may take 30 minutes to 1 hour to start working and can last up to 8 hours. Some common side effects of diclofenac tablets include nausea, vomiting, diarrhea, constipation, headache, dizziness, rash, and liver or kidney problems. Rare but serious side effects include bleeding, ulceration, and perforation of the stomach or intestines, especially in elderly or peptic ulcer patients, and anaphylaxis, a severe allergic reaction. Diclofenac tablets should not be used by pregnant women, breastfeeding women, or children under 14 years old without medical advice.

Diclofenac gel

Diclofenac gelDiclofenac gel is applied topically to the skin at the site of pain or inflammation, up to four times a day, preferably on clean and dry skin. The usual dose for adults is 2 g to 4 g per application, depending on the size of the affected area. Diclofenac gel may take a few minutes to start working and can last up to 12 hours. Diclofenac gel is usually well-tolerated, with minimal absorption into the bloodstream and lower risk of gastrointestinal or systemic side effects compared to oral diclofenac. Some common side effects of diclofenac gel include skin irritation, redness, itching, and dryness. Rare but serious side effects include allergic reactions that can cause angioedema, bronchospasm, or anaphylaxis, as well as Stevens-Johnson syndrome, a rare but severe skin and mucous membrane disorder. Diclofenac gel should not be used on broken, infected, or sunburned skin, or by pregnant or breastfeeding women, or children under 18 years old without medical advice.

So, which is better, oral diclofenac or diclofenac gel? The answer depends on several factors, such as the location and intensity of the pain or inflammation, the patient’s medical history and preferences, and the possible side effects and interactions with other medications. In general, diclofenac gel may be more suitable for localized pain or inflammation, such as in tendinitis or bursitis, whereas diclofenac tablets may be more appropriate for systemic pain or inflammation, such as in rheumatoid arthritis or osteoarthritis. However, the choice should be made by a qualified healthcare provider, based on the latest evidence and guidelines, and taking into account the individual needs and goals of the patient.

If you experience pain or inflammation and are considering diclofenac, talk to your doctor or pharmacist first. They can help you evaluate the benefits and risks of diclofenac tablets or gel, and suggest alternative or complementary treatments if needed.

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